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The diet channel’s ten best tips for successful weight loss – how to lose weight and keep it off.. Ready to lose weight? here’s how to cut calories, curb cravings, and get the body you want—without making yourself crazy or turning to fad diets. get simple food. Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, due to a mean loss of fluid, body fat or adipose.