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Weight loss in the management of obesity is also discussed separately. (see "obesity in adults: overview of management" and "obesity in adults: dietary therapy".) definitions unintentional weight loss – unintentional weight loss is also referred to as involuntary or unintended weight loss . this term excludes weight loss as an expected consequence of treatment (eg, weight loss from diuretic therapy in patients with heart failure) or as a result of a known illness. clinically important. Unexplained weight loss has many causes, medical and nonmedical. often, a combination of things results in a general decline in your health and a related weight loss. sometimes a specific cause isn’t found.. Weight loss are present in over 50 percent of cancer patients at the time of diagnosis. in a study of patients with lung cancer, anorexia was associated with an average intake deficit of only 300 kcal/day . this does not explain the profound weight loss in some patients with cancer cachexia syndrome. cancer cachexia involves complex metabolic abnormalities that decrease muscle mass and.