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Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, due to a mean loss of fluid, body fat or adipose. Diet.com provides diet, nutrition and fitness solutions. use our free weight loss tips and tools, healthy recipes and fitness videos to meet your weight loss goals today!. Background. after weight loss, changes in the circulating levels of several peripheral hormones involved in the homeostatic regulation of body weight occur..