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Choosing a weight loss program. what is the total cost, including any foods or supplements that are required? if you plan to lose more than 15 to 20 pounds, have any health problems, or take medication on a regular basis, talk to your doctor before you start any weight loss program. if you plan to use a very-low-calorie diet,.... Weight loss. the mayo clinic diet is designed to help you lose up to 6 to 10 pounds (2.7 to 4.5 kilograms) during the initial two-week phase. after that, you transition into the second phase, where you continue to lose 1 to 2 pounds (0.5 to 1 kilogram) a week until you reach your goal weight.. Thinking about going on a weight loss program? with so many programs out there, it can be a challenge trying to pick the one that’s right for you. not all programs are created equal. most programs will help you lose weight, but the best ones will help you keep the weight off. while weight loss programs can provide the support you might be.