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The mayo clinic diabetes diet: the #1 new york bestseller adapted for people with diabetes [the weight-loss experts at mayo clinic] on amazon.com. *free* shipping on. Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, due to a mean loss of fluid, body fat or adipose. Obesity, a chronic long-term disease, is simply the accumulation of excess body fat. learn how diet, exercise, medication, and surgery may help with weight loss and.