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Stress can play a big role in weight gain, which is why it’s critical to be aware of why you’re eating at any given time. alexis eggleton, 34, went through this. For these people, who were obese or severely overweight, losing weight was a matter of life and death. here’s their advice for successful weight loss.. Elderly patients with unintentional weight loss are at higher risk for infection, depression and death. the leading causes of involuntary weight loss are depression.